If you're in it for the long haul, you need to be sure that the board's socket or chipset can support this (and preferably the next round of) high-end processors. Now we have to consider the most important thing about motherboards future-proofing.
This isn't always bad, especially if you don't plan on getting a new motherboard for several years.
Before committing to a motherboard, you must ask yourself: How big is your PC case? Do you want to be able to overclock your CPU? Do you need high-performance RAM support? Do you need a block of USB ports? Bluetooth? Wi-fi? If your wish list increases, expect to spend extra.